Sandrena is a transdermal estradiol gel used for hormone replacement therapy (HRT) in menopause. Evidence from randomized controlled trials, systematic reviews, and meta-analyses supports its effectiveness for vasomotor and other menopausal symptoms with a favorable safety profile.
- Vasomotor symptoms: Meta-analyses show transdermal estradiol gels (including Sandrena) effectively reduce hot flashes and night sweats compared with placebo or oral estrogens¹³
- Quality of life: RCTs show significant improvement in menopause-specific quality-of-life scores with estradiol gel use²⁵
- Safety: Transdermal estrogen shows lower risk of VTE and stroke compared to oral HRT, with good tolerability⁴⁵
- Osteoporosis prevention: Systematic reviews and meta-analyses confirmed hormone therapy—including transdermal oestradiol spray—reduces fracture risk and bone loss 6,7
Both NICE and the BMS recognise transdermal estradiol as a valid route of hormone therapy for menopause and imply its role in symptom control and bone health.8,9
References
- Derzko C, Sergerie M, Siliman G, Alberton M. Comparative efficacy and safety of estradiol transdermal preparations for the treatment of vasomotor symptoms in postmenopausal women: an indirect comparison meta-analysis. Menopause. 2016. Link
- Naunton M, Al Hadithy AFY, Brouwers JRBJ. Estradiol gel: review of the pharmacology, pharmacokinetics, efficacy, and safety in menopausal women. Menopause. 2006. Link
- Goldštajn MŠ, Mikuš M, Ferrari FA, Bosco M. Effects of transdermal versus oral hormone replacement therapy in postmenopause: a systematic review. Arch Gynecol Obstet. 2023. Link
- Crandall CJ, Mehta JM, Manson JAE. Management of menopausal symptoms: a review. JAMA. 2023. Link
- Laing A, Hillard T. Oestrogen-based therapies for menopausal symptoms. Maturitas. 2024. Link
- Lin SY, Hung MC, Chang SF, Tsuang FY. Efficacy and safety of postmenopausal osteoporosis treatments: a systematic review and network meta-analysis of randomized controlled trials. J Clin Med. 2021. Link
- Naunton M, Al Hadithy AFY, Brouwers JRBJ. Estradiol gel: review of the pharmacology, pharmacokinetics, efficacy, and safety in menopausal women. Menopause. 2006. Link
- Available from https://www.nice.org.uk/guidance/ng23
- Available from https://thebms.org.uk/publications/consensus-statements/bms-whcs-2020-recommendations-on-hormone-replacement-therapy-in-menopausal-women/
