Oestrogen-containing HRT absorbed through the skin in patches, gels or spray, has been shown to be highly effective for hot flushes and night sweats. 1
There is also high quality evidence and systematic reviews showing it improves bone strength, mood, libido, urinary and vaginal health, as well as heart health when started before age 60. 1
Increasing, but conflicting evidence exists on the benefit in muscle mass and joint health. 1
It is also approved for the prevention of osteoporosis. 1
Norethisterone acetate has very good evidence for protecting the uterus as part of an HRT regimen. Norethisterone may have more androgenic properties than more natural progesterone (micronised progesterone), leading to things like oily skin, acne and hair thinning.2
